Selected Publications

Gu, Y., & Gu, C.* (2014) Physiological and pathological functions of mechanosensitive ion channels. (review article) Molecular Neurobiology In press&​
Barry J, Gu Y, Jukkola P, O’Neill B, Gu H, Mohler PJ, Thirtamara-Rajamani K, & Gu C* (2014) Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons. Developmental Cell   28, 117-131


Jukkola P, Guerrero T, Gray V, & Gu C* (2013) Astrocytes differentially respond to inflammatory autoimmune insults and imbalances of neural activity. Acta Neuropathologica Communications  1, 70


Barry, J., Xu, M., Gu, Y., Dangel, A., Jukkola, P., Shrestha, C., and Gu, C.* (2013) Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels. Journal of Cell Science  126, 2027-2041


​Gu, Y., Barry, J., and Gu, C.* (2013) Kv3 channel assembly, trafficking and activity are regulated by zinc through different binding sites. Journal of Physiology  591, 2491-2507


​Barry, J., and Gu, C.* (2013) Coupling Mechanical Forces to Electrical Signaling: Molecular Motors and the Intracellular Transport of Ion Channels. The Neuroscientist  (review article)  19, 145-159.  Published online on Aug. 24th, 2012
Green, J.A., Gu, C., and Mykytyn, K. (2012) Heteromultimerization of ciliary G-protein coupled receptors in the mouse brain. PLoS One  7, e46304
Gardner, A., Jukkola, P., and Gu, C.* (2012) Myelination of rodent hippocampal neurons in culture. Nature Protocols 7, 1774-1782
Jukkola, P., Lovett-Racke, A.E., Zamvil, S.S., and Gu, C.* (2012) K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.  Neurobiology of Disease   47, 280-293
Gu, Y.Z., Barry, J., McDougle, R., Terman, D., and Gu, C.* (2012) Alternative splicing regulates Kv3.1 polarized targeting to adjust the maximal spiking frequency. The Journal of Biological Chemistry 287, 1755-1769
Gu, C.*, and Gu, Y.Z. (2011) Clustering and activity tuning of Kv1 channels in myelinated Hippocampal axons. The Journal of Biological Chemistry  286, 25835-25847
Gu, C.*, and Barry, J. (2011) Function and mechanism of axonal targeting of voltage-sensitive potassium channels. Progress in Neurobiology (review article) 94, 115-132
Xu, M., Gu, Y.Z., Barry, J., and Gu, C.*  (2010) Kinesin I transports tetramerized Kv3 channels  through the axon initial segment via direct binding. The Journal of Neuroscience 30, 15987-16001
Barry, J., Gu, Y., and Gu, C.* (2010) Polarized targeting of L1-CAM regulates axonal and dendritic bundling in vitro. European Journal of Neuroscience 32, 1618-1631
​Gu, Y., and Gu, C.* (2010) Dynamics of Kv1 channel transport in axons. PLoS One 5, e11931
Xu, M., Cao, R.F., Xiao, R., Zhu, M., and Gu, C.* (2007) The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a conditional signal that associates with the T1 domain and ankyrin G. The Journal of Neuroscience 27, 14158-14170
Gu, C.*, Zhou, W., Puthenveedu, M. A., Xu, M., Jan, Y. N., and Jan, L. Y. (2006) The
microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. Neuron 52, 803-816
Before 2005

Gu, C., Jan, Y. N., and Jan, L. Y. (2003) A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science 301, 646-649
Hu, B., Nakata, H., Gu, C., de Beer, T., and Cooper, D. M. F. (2002) A critical interplay between Ca2+-inhibition and activation by Mg2+ of AC5 revealed by mutants and chimeric constructs. The Journal of Biological Chemistry 277, 33139-33147
Smith, K.E., Gu, C., Fagan, K.A., Hu, B., and Cooper, D. M. F. (2002) Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca2+ entry. The Journal of Biological Chemistry 277, 6025-6031
Gu, C., Cali, J., and Cooper D. M. F. (2002) Dimerization of mammalian adenylyl cyclases, functional, biochemical and fluorescence resonance energy transfer (FRET) studies. European Journal of Biochemistry 269, 413-421



Gu, C., Sorkin, A., and Cooper, D. M. F. (2001) Persistent interactions of the two transmembrane clusters dictate targeting and functional assembly of adenylyl cyclase. Current Biology 11, 185-190
Gu, C., and Cooper, D. M. F. (2000) Ca2+, Sr2+ and Ba2+ identify distinct regulatory sites on adenylyl cyclase (AC) types VI and VIII and consolidate the apposition of capacitative cation entry channels and Ca2+-sensitive ACs. The Journal of Biological Chemistry 275, 6980-6986
Gu, C., and Cooper, D. M. F. (1999) Calmodulin-binding sites on adenylyl cyclase type VIII. The Journal of Biological Chemistry 274, 8012-8021
Weiner, J. L., Gu, C., and Dunwiddie, T. V. (1997) Differential ethanol sensitivity of subpopulations of GABAA synapses onto rat Hippocampal CA1 pyramidal neurons. Journal of Neurophysiology 77, 1306-1312
​Shi, Y.L., Gu, C., and Xu, Y.F. (1997) Four types of potassium channels in motor nerve terminals of snake. Science in China (Series C) 40(6), 593-603
Gu, C., and Shi, Y.L. (1996) Calcium channel and its pharmacological properties in motor nerve terminals of snake. Chinese Journal of Physiological Sciences 12(2), 149-156
Gu, C., and Shi, Y. L. (1996) Feedback regulation of ion channel activity by acetylcholine (ACh) in snake motor nerve terminals. Acta Physiologica Sinica 48, 529-535
Shi, Y.L., Xu, Y.F., Gu, C., and Li, Y. (1995) Reversible elimination of K+ and Na+ currents at motor nerve terminals by SM486, a derivative of Artemisinin. Acta Physiologica Sinica 47(1), 25-30